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Florida Atlantic University & Max Planck Florida Institute - Integrative Biology and Neuroscience
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Integrative Biology and Neuroscience Faculty - Dr. Ken Dawson-Scully

 

Dr. Ken Dawson-Scully

Assistant Professor, Department of Biological Sciences
College of Science
Florida Atlantic University

Research Description

Since the origin of life, organisms have been exposed to dynamic and unpredictable environments that have bred adaptations to buffer internal physiological functioning from external fluctuations. The evolution of complex nervous systems, and the behaviors they subserve, has played a fundamental role in shaping mechanisms for maintaining homeostasis in the face of environmental perturbations. Adapted animals, such as insects, employ genetic, molecular, and physiological strategies to prevent specific neurological pathologies resulting from stressors such as low oxygen (anoxia), high temperatures (hyperthermia), and high levels of free radicals (oxidative stress). My research program is poised to take advantage of this through the use of a genetically tractable model system, the fruit fly Drosophila melanogaster. In the recent past Drosophila has been used to successfully model a number of human disorders such as Alzheimer's, Parkinson's and obesity. Advantages of the fruit fly include its short life-cycle, high fecundity, sequenced genome and amenability to genetic manipulation. Such characteristics, combined with a general conservation of cellular processes between flies and humans, make Drosophila an ideal system to study cellular pathways associated with neural failure following severe trauma, and to develop novel therapies targeting molecules that contribute to neural dysfunction and cell death/damage. Our goal is to develop novel methods for maintaining both neural function and survival during such instances.

Research Interests

  • Neurobiology of cellular stress and neuroprotection
  • Using live cell imaging
  • Electrophysiology
  • Behavior genetics

Education

  • Ph.D., University of Toronto, Physiology (2003)

Recent Publications

  • Chen, A., Kramer, E., Krill, J., Purpura, L., Zars, T., Dawson-Scully, K., 2011, Influence of natural variation at the foraging gene on thermotolerance in adult Drosophila in a narrow temperature range. J. Comp. Physiol. A Aug 23. [Epub ahead of print]
  • Dawson-Scully K, Bukvic D, Chakaborty-Chatterjee M, Ferreira R, Milton SL, and Sokolowski MB 2010. Controlling anoxic tolerance in adult Drosophila via the cGMP-PKG pathway. J Exp Biol. Jul 15;213(Pt 14):2410-6.
  • Armstrong GA, López-Guerrero JJ, Dawson-Scully K, Peña F, Robertson RM. 2010, Inhibition of protein kinase G activity protects neonatal mouse respiratory network from hyperthermic and hypoxic stress. Brain Res 1311:64-72.
  • Dawson-Scully K, Armstrong GAB, Kent C, Robertson RM, and Sokolowski MB, 2007. Natural variation in the thermotolerance of neural function and behavior due to a cGMP dependent protein kinase. PLoS ONE: 2(8): e773.
Click here for most recent publications

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