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Florida Atlantic University & Max Planck Florida Institute - Integrative Biology and Neuroscience
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Integrative Biology and Neuroscience Faculty - Dr. Greg Macleod

 

Dr. Greg Macleod

(561) 799-8205

Associate Professor
College of Science
Florida Atlantic University

Research Description

Rapid communication between cells is the basis for most of the functions of the nervous system, including sensory transduction, learning, memory, and locomotion. Most cells of the nervous system communicate at synapses, specialized sites at which closely opposed cells release chemicals known as neurotransmitters. Our laboratory investigates the release of neurotransmitters from nerve cells and factors that influence their release, such as mitochondria, pH, and age. We use electrophysiology and high-speed fluorescence imaging to construct a molecular, biophysical, and physiological understanding of neurotransmitter release. We conduct our studies primarily in the fruit fly because of its molecular genetic advantages but also conduct studies in mice to examine the effects of mitochondrial dysfunction and age on neurotransmitter release in a vertebrate nervous system.

Research Interests

  • The ways in which mitochondria support neurotransmission and influence synaptic plasticity
  • The mechanisms responsible for pH homeostasis at synapses and their influence on synaptic plasticity
  • The mechanisms supporting neurotransmission most vulnerable to aging

Education

  • PhD., University of Sydney, Physiology (2000)

Recent Publications

  • Shi, Y., Ivannikov, M.V., Walsh, M.E., Liu, Y., Zhang, Y., Jaramillo, C.A., Macleod, G.T., and Van Remmen, H. (2014) The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice. PLoS One 9:e100834.
  • Ivannikov, M.V. and Macleod G.T. (2013) Mitochondrial free Ca2+ levels and their effects on energy metabolism in Drosophila motor nerve termini. Biophys J 104:2353-2561.
  • Rossano, A.J., Chouhan, A.K. and Macleod, G.T. (2013) Genetically-encoded pH-indicators (GEpHIs) reveal activity-dependent cytosolic acidification of Drosophila motor nerve termini in vivo. J Physiol 591:1691-1706.
  • Chouhan, A.K., Ivannikov, M.V., Lu, Z., Sugimori, M., Llinas, R.R. and Macleod, G.T. (2012) Cytosolic calcium coordinates mitochondrial energy metabolism with presynaptic activity. J Neurosci 32:1233-1243.

IBAN Faculty List

FAU Campuses: Boca Raton/Davie/Dania Beach/Fort Lauderdale/Jupiter/Treasure Coast/Harbor Branch
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