Department of Chemistry and Biochemistry
Instrumentation
Nuclear Magnetic Resonance
The Final Exam is on Mon 12/8 at 4pm in Room GS-101
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Fall Semester 2008 |
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Mo & We 4:00-5:20am |
Classroom: GS-101 |
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Instructor: Dr. Frank Mari (mari@fau.edu) |
Office: SEB-134 |
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Office Hours TU, TH 11:00-12:00n |
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FAU's NMR
Course Home Page: http://www.science.fau.edu/chemistry/mari/instr-nmr.html
Required Textbooks:
J. B. Lambert, H. F. Shurvell, D. A. Lightner and R. G. Cooks, “Organic Structural Spectroscopy”,
1998
J. P. Hornak, "The Basics of NMR", http://www.cis.rit.edu/htbooks/nmr,
1997
The NMR Periodic Table: http://bmrl.med.uiuc.edu:8080/MRITable/
Recommended Texts:
H. Friebolin, "Basic 1 and 2D NMR
Spectroscopy", 3rd Ed., Wiley, 1998.
T. J. Logan, "Macromolecular NMR spectroscopy", http://www.sb.fsu.edu/~logan/, 2000
S. Braun, H. O. Kalinowski and S. Berger, "150
and More Basic NMR Experiments", VCH, Weinhein,
1999
ftp://ftp.bruker.de/pub/nmr/courses+manuals/100_NMR_Experiments/150_and_more_v2.pdf
J. K. M. Sanders and B. K. Hunter, "Modern NMR Spectroscopy", 2nd
Ed., Oxford, 1993.
J. K. M. Sanders, E. C. Constable, B. K. Hunter and C. M.
Pearce, "Modern NMR Spectroscopy, a Workbook of Chemical Problems",
2nd Ed.,
MATERIAL TO BE COVERED
Part I: General Principles
A. Historical background and evolution of NMR techniques
B. The nature of the NMR phenomena
C. Modern Instrumentation
D. Magnets, Probes, RF-hardware
E. Sample preparation and handling
F. Pulse Field Gradients
G. Waveform Generators and Pulse Shaping
H. Computer interfaces, software and data handling
Part II: 1D NMR experiments
A. The one-pulse experiment
B. Data processing and handling
C. Spin decoupling and difference spectroscopy
D. Multiple-pulse experiments
E. Shaped pulse experiments
F. Gradient experiments
G. Relaxation techniques. Determination of T1 and T2
Part III: Multidimensional NMR experiments
A. The 2D experiment: Basic concepts and properties of the second dimension
B. Connections through bonds. Homonuclear and Heteronuclear experiments
C. Connections through space. The Nuclear Overhauser
Effect.
Part IV: Practical Applications of NMR spectroscopy.
A. Multinuclear NMR and its applications to small molecules: The Taxol case study
B. Multinuclear NMR and its applications to Biological chemistry
C. Applications to microsampling, LC- NMR and
combinatorial chemistry
D. Biomedical NMR and Magnetic Resonance Imaging.
Lectures
Lecture
1
Lecture
2
Lecture
3
Lecture
4
Lecture 5
Lecture 6
Useful NMR Links
The National High Field Magnet Lab
(
Varian NMR Instruments Homepage (
NMR Information Server (
University of Minnesota NMR Lab Homepage at the Department of Chemistry. A well-organized homepage that contains instructions for the operation of the Varian Unity Inova spectrometers. It also has several tips on the how to run NMR experiments according to your structural elucidation needs.
2D NMR by Marc BRIA, Pierre WATKIN & Yves PLANCKE (France) An excellent home page that contains interactive examples on the principles and applications of the most popular 2D NMR experiments (it is also in French, if you would like to practice the language)
Exam Sets