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Research
The focus of our research program is the development of synthetic organic methods and their application to the synthesis of therapeutically important compounds. Our efforts are concentrated in several areas:
- The total synthesis of complex natural products and related analogs for structure activity relationship studies: the molecular targets we choose to pursue in these synthetic studies are expected to deepen our understanding of the biological process in which they intervene.
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The development of expedited synthesis techniques to facilitate small-molecule library production: In this aspect of
our research,
we look at ways to simplify the process of making molecules by developing a variety of new methods both on polymer support and in solution.
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Nucleophile assisting leaving groups (NALGs) for increased speed and precision in molecular construction: we have identified new reactions enabled by chelating leaving groups including fast radiolabeling with F18 for medical imaging applications (PET).
- One of our NALG reagents is now commercially available at
Sigma-Aldrich.
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