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Dr. Andrew Terentis
Associate Professor
PhD: University of Sydney
BSc: University of Sydney

Contact information
Office: S&E 246
Phone: (561) 297-0653
Fax:      (561) 297-2759
Email:   terentis@fau.edu


Research

Research in the Terentis lab aims to develop an understanding of the structure and function of biomolecules, living cells, and biological tissues through the application of Raman spectroscopy and microscopy as well as other optical spectroscopic techniques.  Specific research projects in the laboratory include:

Confocal Raman Microscopy Analysis of Skin Cancers
Confocal Raman microscopy (CRM) is applied to the study of single, living skin cancer cells as well as skin tissue specimens in order to determine the biochemical characteristics of skin cancers and to develop CRM as a tool for clinical diagnoses.

Function and Regulation of Indoleamine 2,3-Dioxygenase (IDO)
A range of optical spectroscopy techniques are employed, including resonance Raman, CRM, circular dichroism and UV-Visible absorption, as well as enzyme kinetic measurements to determine the mechanisms of inhibition of IDO by small-molecule inhibitors.

Structure-Function Studies of Cell-Penetrating Peptides
The interactions of cell-penetrating peptides with living cells are studied with CRM and fluorescence microscopy.  The secondary structures of CPPs in various solvent environments are further characterized by polarized Raman spectroscopy and CD.  Experimental measurements are supported by computational studies of peptide structure.

Structural Studies of G-quadruplexes
The structure of G-rich oligonucleotides that have the potential to form G-quadruplexes are studied with a variety of optical spectroscopic techniques, including polarized Raman, surface-enhanced Raman (SERS), CD, UV-Visible absorption, and fluorescence spectroscopy.

 

Peer-Reviewed Publications

AC Terentis, J Ye (2013) Peptide detection and structure determination in live cells using confocal Raman microscopy, Methods in Molecular Biology, submitted.

AC Terentis, SA Fox, SJ Friedman, ES Spencer (2013) Confocal Raman micro-spectroscopy discriminates live human metastatic melanoma and skin fibroblast cells, J Raman Spectrosc, submitted.

M Freewan, M Rees, TS Sempértegui Plaza, E Glaros, YJ Lim, X-S Wang, AWS Yeung, PK Witting, AC Terentis, SR Thomas (2013) Human Indoleamine 2,3-Dioxygenase is a Catalyst of Physiological Heme Peroxidase Reactions – Implications for the Inhibition of Dioxygenase Activity by Hydrogen Peroxide, J Biol Chem 288, 1548-1567.

 AC Terentis, M Freewan, TS Sempértegui Plaza, M Raftery, R Stocker, SR Thomas (2010) The Selenazal Drug Ebselen is a Potent Inhibitor of Indoleamine 2,3-Dioxygenase by Targeting Enzyme Cysteine Residues, Biochemistry 49, 591-600. 

J Ye, SA Fox, M Cudic, EM Rezler, JL Lauer, GB Fields, AC Terentis (2010) Determination of Penetratin Secondary Structure in Live Cells with Raman Microscopy, J Am Chem Soc 132, 980-988.

 SW Vetter, AC Terentis, RL Osborne, JH Dawson, DB Goodin (2009) Replacement of the Axial Histidine Heme Ligand with Cysteine in Nitrophorin-1: Spectroscopic and Crystallographic Characterization, J Biol Inorg Chem 14, 179-191.

SR Thomas, AC Terentis, H Cai, O Takikawa, A Levina, P Lay, M Freewan, R Stocker (2007) Post-translational regulation of human indolamine 2,3-dioxygenase activity by nitric oxide, J Biol Chem 282, 23778-23787.

 AC Terentis, L Ujj, H Abramczyk, GH Atkinson (2005) Primary events in the bacteriorhodopsin photocycle: torsional vibrational dephasing in the first excited electronic state, Chem Phys 313, 51-62.

 AC Terentis, Y Zhou, GH Atkinson, L Ujj (2003) Picosecond time-resolved coherent anti-Stokes Raman spectroscopy of the artificial bacteriorhodopsin pigment BR6.11, J Phys Chem A 107, 10787-10797. 

AC Terentis, SR Thomas, O Takikawa, TK Littlejohn, RJW Truscott, RS Armstrong, S-R Yeh, R Stocker (2002) The heme environment of recombinant human indoleamine 2,3-dioxygenase - structural properties and substrate-ligand interactions, J Biol Chem 277, 15788-15794.

 JM Upston, AC Terentis, K Morris, JF Keaney, Jr., R Stocker (2002) Oxidized lipid accumulates in the presence of a‑tocopherol in atherosclerosis, Biochem J 363, 753-760.

 AC Terentis, SR Thomas, JA Burr, DC Liebler, R Stocker (2002) Vitamin E oxidation in human atherosclerotic lesions, Circ Res 90, 333-339. (Cited as one of the top 25 papers for 2002 in the Annual Bibliography of Significant Advances in Dietary Supplement Research 2002 by the National Institutes of Health, Office of Dietary Supplements)

 R Stocker, AC Terentis, JM Upston, L Kritharides (2002) Is there a role for vitamin E in the prevention of atherosclerosis?, in The antioxidant vitamins C and E, Packer L, Traber M, Kraemer K, Frei B, Eds; (AOCS Press, Champaign, IL), 228-242.

 GF Metha, AC Terentis, SH Kable (2002) Near-threshold photochemistry of propanal. Barrier height, transition state structure, and product state distributions for the HCO channel, J Phys Chem A 106, 5817-5827.

 JM Upston, AC Terentis, R Stocker (1999) Tocopherol-mediated peroxidation (TMP) of lipoproteins: implications for vitamin E as a potential antiatherogenic supplement, FASEB J 13, 977-994.

 AC Terentis, SE Waugh, GF Metha, SH Kable (1998) HCO (N, Ka, Kc, J) distributions from near-threshold photolysis of H2CO (J, Ka, Kc), J Chem Phys 108, 3187-3198.

 SE Waugh, AC Terentis, GF Metha, SH Kable (1998) Conservation of angular momentum in polyatomic photochemical reactions: H2CO (n, J, Ka, Kc) ® H + HCO (N, Ka, Kc, J), Proc SPIE 3271, 36-46.

 R Stocker, JM Upston, X Nui, AC Terentis, V Zammit, LJ Hazell, S Fu, RT Dean (1998) Lipoprotein oxidation in human atherosclerosis, in Atherosclerosis XI: proceedings of the XIth international symposium on atherosclerosis, Paris, October 5-9, 1997, Jacotot B, Mathé D, Fruchart J-C, Eds; International Congress Series 1155, 475-482.

 AC Terentis, SH Kable (1996) Near-threshold dynamics and dissociation energy of the reaction H2CO ® HCO + H, Chem Phys Lett 258, 626-632.

 AC Terentis, PT Knepp, SH Kable (1995) Radical channel photodissociation dynamics of aliphatic aldehydes: the nascent state distribution of the HCO photoproduct, Proc SPIE 2548, 328-339.

 PT Knepp, AC Terentis, SH Kable (1995) Photodissociation dynamics of NO2 at 309.1 nm, Proc SPIE 2548, 316-327.

 PT Knepp, AC Terentis, SH Kable (1995) Photodissociation dynamics of NO2 at moderately high available energy (l = 309 nm; Eavail = 7220 cm-1), J Chem Phys 103, 194-204.

 AC Terentis, PT Knepp, SH Kable (1995) Nascent state distribution of the HCO photoproduct arising from the 309 nm photolysis of propionaldehyde, J Phys Chem 99, 12704-12710.

 AC Terentis, M Stone, SH Kable (1994) Dynamics of acetaldehyde dissociation at 308 nm: rotational (N,Ka) and translational distributions of the HCO photoproduct, J Phys Chem 98, 10802-10808.

 AC Terentis, A Doughty, JC Mackie (1992) Kinetics of pyrolysis of a coal model-compound, 2-picoline, the nitrogen heteroaromatic analogue of toluene, J Phys Chem 96, 10334-10339.


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