Research
1. Development of new and elite courses for the Undergraduate Organic Chemistry curriculum incorporating novel teaching
techniques and technologies designed to enhance student learning.
2. Development and redevelopment of Organic Chemistry Lab experiments and the course in general to facilitate greater exposure
to analytical and specifically spectroscopic techniques such as NMR for undergraduate chemistry students.
3. Ongoing research-using spectroscopic techniques to
investigate the mechanism of drug delivery by cell selective cell penetrating peptides to cancer cells.
Recent Publications D.R. Khan, E.M. Rezler, J. Lauer-Fields, G.B. Fields, "Effects of Drug Hydrophobicity on Liposomal Stability" Chem. Biol. Drug Des.
71, 3-7 (2008).
Y. Qin, E.M. Rezler, V. Gokhale, D. Sun, L.H. Hurley, "Characterization of the G-quadruplexes in the duplex nuclease hypersensitive
element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4" Nucleic Acids Res. 35(22), 7698-7713 (2007).
E.M. Rezler, D.R. Khan, J. Lauer-Fields, M. Cudic, D. Baronas-Lowell, G.B. Fields, “Targeted drug delivery utilizing protein-like
molecular architecture,” J. Am. Chem. Soc. 129, 4961- 4972 (2007).
E.M. Rezler, D.R. Khan, R. Tu, M. Tirrell, G.B. Fields, “Peptide-Mediated Targeting of Liposomes to Tumor Cells”, Methods Mol. Biol. 386,
269-298 (2007).
E. M. Rezler, J. Seenisamy, S. Bashyam, M.Y. Kim, E. White, W.D. Wilson, L.H. Hurley, “Telomestatin and diseleno sapphyrin bind selectively
to two different forms of the human telomeric G-quadruplex structure,” J. Am. Chem. Soc. 127, 1439-1447 (2005).
J. Seenisamy, E.M. Rezler, T.J. Powell, V. Gokhale, M.D. Tye, A. Siddiqui-Jain, L.H. Hurley, “The Dynamic Character of the G-Quadruplex Element
in the c-MYC Promoter and the Product upon Modification by TMPyP4,” J. Am. Chem. Soc. 126, 8702-8709 (2004).
E.M. Rezler, D.J. Bearss, L.H. Hurley, “Telomere inhibition and telomere disruption as processes for drug targeting,” Annu. Rev. Pharmacol.
Toxicol. 43, 359-379 (2003).
E.M. Rezler, D.J. Bearss, L.H. Hurley, “Telomeres and telomerases as drug targets,” Curr. Opin. Pharmacol. 2, 415-423 (2002).
T.W.Hambley, S.J. Berners-Price, M.S. Davies, C.I. Diakos, H.M. Er, R.R. Fenton, E.C.H. Ling, E.M. Rezler, “Steric Determinants of Pt/DNA Interactions
and Anticancer Activity,” Metal-Based Drugs 5, 197-206 (1998).
E.M. Rezler, R.R. Fenton, W.J. Esdale, M.J. McKeage, P.M. Russell, T.W. Hambley, “Preparation, Characterization, DNA Binding, and in Vitro Cytotoxicity of the Enantiomers of the Platinum(II) Complexes N-Methyl, N-Ethyl- and N,N-Dimethyl-(R)- and -(S)-3-aminohexahydroazepinedichloroplatinum(II)”
J. Med. Chem. 40, 3508-3515 (1997).
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