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Dr. Predrag Cudic
Associate Professor
PhD: University of Zagreb
Rudjer Boskovic Institute
BS: Collège de France
Contact information
Office: S&E 138
Phone: (561) 297-3819
Fax: (561) 297-2759
Email: pcudic@fau.edu
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Research
Bioorganic/Biomimetic Chemistry, Synthetic Organic Chemistry, Peptide Chemistry, Molecular Recognition.
Our research interest is focused on design, synthesis and evaluation of biologically active organic compounds.
This encompasses development of new chemotherapeutics and chemosensors, solution and solid-phase synthesis and methodology, structure-activity
relationship studies, combinatorial chemistry, and elucidation of the mode of action at the molecular level of some active compounds.
The following projects are currently underway:
Cyclic depsipeptides: promising lead compounds for drug discovery
Novel organo-peptide anticancer drugs and diagnostics that target tumor cells specific carbohydrates.
Journal Publications
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P. Cudic, B. Klaic, Z. Raza, D. Sepac, V. Sunjic, Synthesis and Properties of Some Rh(I) Catalytic Complexes with Dinitrogen Ligands from 5-Pyrido-1,4-benzodiazepin-4-ones, Tetrahedron, 47 (1991) 5295.
- M. Zinic, P. Cudic, V. Skaric, J. P. Vigneron, J. M. Lehn, Cyclo-bis-intercaland Receptors with Phenanthridine Subunits, Tetrahedron Lett. 33 (1992) 7417
- P. Cudic, M. Zinic, V. Tomisic, Vl. Simeon, J. P. Vigneron, J. M. Lehn, Binding of Nucleotides in Water by Phenanthridinium Bis(intercaland) Receptor Molecules, J. Chem. Soc. Chem. Commun. (1995) 1073.
- P. Cudic, M. Zinic, V. Skaric, R. Kiralj, B. Kojic-Prodic, J. P. Vigneron, J. M. Lehn, Synthesis of Cyclo-bis-intercaland Receptor Molecules with Phenanthridinium Units, Croat. Chem. Acta. 69 (1996) 569.
- P. Cudic, M. Zinic, Supramolecular Chemistry. Artificial Receptors for Binding and Recognition of Nucleotide in Aqueous Media, Period. Biol. 98 (1996) 283.
- P. Cudic, J. P. Vigneron, J. M. Lehn, M. Cesario. T. Prange, Molecular Recognition of Azobenzene Dicarboxylate by Acridine-based Receptor Molecules. Crystal Structure of the Supramolecular Inclusion Complex of trans-3, 3'-Azobenzene Dicarboxylate with Cyclo-bis-intercaland receptor, Eur. J. Org. Chem. (1999) 2479.
- G. McCafferty, P. Cudic, M. K. Yu, D. C. Behenna, R. G. Kruger, Synergy and Duality in Peptide Antibiotic Mechanism, Curr. Opin. Chem. Biol. 3 (1999) 672.
- P. Cudic, D. C. Behenna, M. K. Yu, R. G. Kruger, L. Szewczuk, D. G. McCafferty, Synthesis of P1-Citronellyl-P2-?-D-pyranosyl Pyrophosphate as Potential Substrates for the E. coli Undecaprenyl-pyrophosphoryl-N-acetylglucoseaminyl transferase MurG, Bioorg. Med. Chem. Lett. 11 (2001) 3107.
- Piantanida, B. S. Palm, P. Cudic, M. Zinic, H. J. Schneider, Phenanthridinium Cyclobisintercalands. Fluorescence Sensing of AMP and selective binding to Single-stranded Nucleic Acids, Tetrahedron Lett. 42 (2001) 6779.
- P. Cudic, J. K. Kranz, D. C. Behenna, R. G. Kruger, H. Tadesse, Y. I. Veklich, J. W. Weisel, A. J. Wand, D. G. McCafferty, Complexation of Peptidoglycan Intermediates by the Lipoglycodepsipeptide Antibiotic Ramoplanin: Minimal Structural Requirements for Intermolecular Complexation and Fibril Formation, Proc. Nat. Acad. Sci. USA 99 (2002) 7384.
- P. Cudic, D. C. Behenna, J. K. Kranz, R. G. Kruger, A. J. Wand, Y. I. Veklich, J. W. Weisel, D. G. McCafferty, Functional Analysis of the Lipoglycodepsipeptide Antibiotic Ramoplanin, Chem. Biol. 9 (2002) 897.
- G. McCafferty, P. Cudic, B. A. Frankel, S. Barkallah, R. G. Kruger, W. Li, Chemistry and Biology of the Ramoplanin Family of Peptide Antibiotics, Biopolymers (Peptide Science) 66 (2002) 261.
- Piantanida, B. S. Palm, P. Cudic, M. Zinic, H. -J, Schneider, Interactions of Acyclic and Cyclic Bis-Phenanthridinium Derivatives with ss- and ds-Polynucleotides, Tetrahedron, 60 (2004) 6225.
- L. Otvos, Jr., V. De Olivier Inacio, J. D. Wade, P. Cudic, Prior Antibacterial Peptide-Mediated Inhibition of Protein Folding in Bacteria Mutes Resistance Enzymes, Antimicrob. Agents Chemother. 50 (2006), 3146.
- M. Stawikowski and P. Cudic, A Novel Strategy for the Solid-phase Synthesis of Cyclic Lipodepsipeptides, Tetrahedron Lett. 47 (2006) 8587.
- P. Cudic, M. Stawikowski, Pseudopeptide Synthesis via Fmoc Solid-Phase Synthetic Methodology, Mini. Rev. Org. Chem. 4 (2007) 268.
- L. Otvos, Jr., M. Terrasi, S. Cascio; M. Cassone, G. Abbadessa, F. De Pascali, L. Scolaro, D. Knappe, M. Stawikowski, P. Cudic, J. D. Wade, R. Hoffmann, E. Surmacz, Development of a Pharmacologically Improved Peptide Agonist of the Leptin Receptor, BBA-Mol. Cell. Res. 1783 (2008) 1745.
- M. Cassone, P. Vogiatzi, R. La Montagna, V. De Olivier Inacio, P. Cudic, J. Rux, L. Otvos, J. Wade, Scope and Limitations of the Designer Proline-rich Antibacterial Peptide Dimer, A3-APO, Alone or in Synergy with Conventional Antibiotics, Peptides, 29 (2008) 1878.
Book Chapters
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P. Cudic, J. K. Kranz, D. C. Behenna, R. G. Kruger, A. J. Wand, D. G. McCafferty, Complexation of Peptidoglycan Intermediates by the Lipoglycodepsipeptide Antibiotic Ramoplanin: Structural Requirements for Intermolecular Complexation and Fibril Formation, Peptides: The Wave of the Future, edited by R. Hougten, American Peptide Society, (2001) 512.
- R. Rawat, R. T. Martello, P. Y. Jean-Charles and P. Cudic, Progress Toward Total Solid-Phase Synthesis of Cyclic Lipodepsipeptide Antibiotic Fusaricidin A, In Understanding Biology Using Peptides, American Peptide Society, edited by Sylvie E. Blondelle, American Peptide Society, (2005) p. 271-272.
- M. Stawikowski and P. Cudic, Depsipeptide Synthesis, In Methods in Molecular Biology, edited by Gregg B. Fields, Humana Press, (2006) vol. 386, p. 321-339.
- L. Otvos, Jr., V. de Olivier Inacio, M. Cassone, J. D. Wade, and P. Cudic, Synergy between Antibacterial Peptides and Antibiotics, In Peptides 2006, edited by K. Rolka, P. Rekowski, and J. Silberring, Kenes International, Geneva, Switzerland, , (2007) pp. 104-105.
- M. Stawikowski and P. Cudic, Optimization of the Total Solid-Phase Synthesis of Lipodepsipeptide Antibiotic Fusaricidin A, In Peptides 2006, edited by K. Rolka, P. Rekowski, and J. Silberring, Kenes International, Geneva, Switzerland, (2007) p. 321-322.
- C. James-Johnson, P. Cudic, Bicyclic Organo-Peptides as Models for Carbohydrate Binding Proteins, In Peptides for Youth, edited by E. Escher, W. D. Lubell, S. Del Valle, American Peptide Society, (2009) in press.
- M. Stawikowski, P. Cudic, Lipodepsipeptide Antibiotic Fusaricidin and its Analogues: Total Solid-Phase Synthesis and Biological Activity, In Peptides for Youth, edited by E. Escher, W. D. Lubell, S. Del Valle, American Peptide Society, (2009) in press.
- R. Stawikowska, M. Stawikowski, P. Cudic, Progress toward Total Solid-Phase Synthesis of Depsipeptide Antibiotic Katanosin B, In Peptides for Youth, edited by E. Escher, W. D. Lubell, S. Del Valle, American Peptide Society, (2009) in press.
- L. Otvos, Jr., M. Cassone, V. De Olivier Inacio, P. Noto, J. J. Roux, J. D. Wade, P. Cudic, Synergy Between a Lead Proline-Rich Antibacterial Peptide Derivative and Small Molecule Antibiotics, In Peptides for Youth, edited by E. Escher, W. D. Lubell, S. Del Valle, American Peptide Society, (2009) in press.
- L. Otvos, Jr., M. Cassone, M. Terrasi, S. Cascio, G. Mateo, D. Knappe, R. Hoffmann, P. Cudic, J. D. Wade, E. Surmacz, Agonist and Partial Antagonists Acting on the Leptin-Leptin Receptor Interface, Peptides for Youth, edited by E. Escher, W. D. Lubell, S. Del Valle, American Peptide Society, (2009) in press.
- P. Cudic, M. Stawikowski, Peptidomimetics: Fmoc Solid-Phase Pseudopeptide Synthesis, In Methods in Molecular Biology, edited by Laszlo Otvos, Jr., Humana Press, (2008) vol. 494, p. 219-242.
Patent
P. Cudic, Artificial Carbohydrate Receptors and Methods for Use Thereof, Patent application, (2008), FAU case number: 2008-07, Docket number: 6818-172/2008-07
Grants
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Agency: Florida Atlantic University, Start-up fund
Principal Investigator: Predrag Cudic
- Agency: National Institutes of Health (NIH), Grant ID: 1S06-GM073621-01, SCORE Pilot Project
Title of Project: New Depsipeptide Antibiotics and Their Bacterial Targets
Principal Investigator: Predrag Cudic
- Agency: American Heart Association (AHA), National Center Research Program, Grant ID: 0630175N
Title of Project: New Antibiotic Therapy for the Treatment of Infective Endocarditis
Principal Investigator: Predrag Cudic
- Agency: NATO, Science for Peace Grant, Grant ID: SfP-983154
Title of Project: Artificial Receptors for Bacillus anthracis Specific Anthrose Detection
Principal Investigator: Predrag Cudic
- Agency: Unity through Knowledge Fund, Republic of Croatia, Ministry of Science, Education and Sport Postdoctoral research grant
Title of Project: Antibiotic plusbacin A3: total solid-phase synthesis and structure-activity relationship study
Co-Principal Investigator: Predrag Cudic
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