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Tanja Angela Godenschwege
Assistant Professor
PhD: Bayerische Julius-Maximilians-Universität Würzburg, Germany
Research interests: My lab uses the fruit fly Drosophila melanogaster as a model to
understand brain development and function. In the nervous system the
function and signaling mechanisms of many genes are evolutionarily
conserved from flies to humans. We use anatomical,
electrophysiological, molecular and genetic tools to analyze the
roles these genes play in the assembly of a neuronal circuit and how
developmental processes such as axon guidance and synapse formation
are affected when they are mutated. Currently in the lab we are
characterizing several genes such as L1-CAM/Neuroglian, Semaphorin,
and Superoxide Dismutase (SOD). These genes are of relevance to a
variety of neurological disorders and diseases such as CRASH syndrome
(split brain), regeneration & degeneration, cancer and aging.
Contact information
Office: SC209 (office) and SC225 (lab)
Phone: (561) 297-1390 (Office), (561) 297-0439 (Lab)
e-mail: godensch@fau.edu |
Godenschwege, T. A.; Kristiansen L. V., Uthaman B. S., Hortsch, M. and Murphey, R. K. (2006): " A Conserved Role for Drosophila Neuroglian and human L1-CAM in Central Synapse Formation " . Current Biology, Jan 10;16(1):12-23.
Allen, M. J.; Godenschwege, T. A.; Mark A. Tanouye, Pauline Phelan (2005): " Making an escape: Development and function of the Drosophila Giant Fibre System " . Sem Cell Dev Biol Review.
Godenschwege T. A., Reisch D., Diegelmann S., Eberle K., Funk N., Heisenberg M., Hoppe V., Hoppe J., Klagges B. R. E., Martin J.-R., Nikitina E. A., Putz G., Reifegerste R., Reisch N., Riester J., Schaupp M., Scholz H., Schwärzel M., Werner U., Zars T. D., Buchner S., Buchner E. (2004): "Flies lacking all synapsins are unexpectedly healthy but are impaired in complex behaviour". European Journal of Neuroscience 20(3):611-622.
Murphey, R. K.; Froggett, S. J.; Caruccio, P.; Shan-Crofts, X.; Kitamoto, T.; Godenschwege, T. A. (2003): Targeted expression of shibire(ts) and semaphorin 1a reveals critical periods for synapse formation in the giant fiber of Drosophila.
Development 130(16):3671-82.
Godenschwege, T. A.; Hu H., Shan, X.; Goodman, C. S. and Murphey, R. K. (2002): " Bi-directional signaling by Semaphorin1a during central synapse formation in Drosophila " . Nature Neuroscience 5(12):1294-301 .
Löhr, R.; Godenschwege, T. A.; Buchner, E.; Technau, G.; Prokop, A. (2002):" Compartmentalisation of central neurons in Drosophila: a new strategy of mosaic analysis reveals localisation of pre-synaptic sites to specific segments of neurites". Journal of Neuroscience 22(23):10357-67.
Murphey, R. K. and Godenschwege, T.A.(2002): "New Roles for Ubiquitin in the Assembly and Function of Neuronal Circuits". Neuron 36 (1): 5-8.
Godenschwege, T. A.; Simpson, J. H.; Shan, X.; Bashaw, G. J.; Goodman, C. S. and Murphey, R. K. (2002): Ectopic Expression in the Giant Fiber System of Drosophila Reveals Distinct Roles for Robo, Robo2 and Robo3 in Dendritic Guidance and Synaptic Connectivity.Journal of Neuroscience 22(8): 3117-3129.
Godenschwege, T. A.; Buchner, S.; Pohar, N.; Buchner, E. (2000): "Insect tissue inhibitor of metalloproteinases: Inflated wings, tissue autolysis, and early death in TIMP mutants of Drosophila". European Journal of Cell Biology 79(7): 495-501. COVER ART.
Pohar, N.; Godenschwege, T. A.; Buchner, E. (1999): "Invertebrate Tissue Inhibitor of Metalloproteinase: Structure and Nested Gene Organization within Synapsin Locus is Conserved from Drosophila to Man", Genomics 57(2), 293-296.
Klagges, B. R. E.; Heimbeck, G.; Godenschwege, T. A.; Hofbauer A.; Pflugfelder, G. O.; Reifegerste, R.; Reisch, D.; Schaupp, M.; Buchner S.; Buchner, E. (1996): "Invertebrate Synapsins: A Single Gene Codes for Several Isoforms in Drosophila", Journal of Neuroscience 16(10), 3154-3165.
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