Kasirajan Ayyanathan Associate Professor PhD: Indian Institute of Science, 1994 Research interests: Transcriptional Regulation; Chromatin; Epigenetics; Cancer Contact information Office:SC 209 Phone: (561) 297-1288 Email: kayyanat@fau.edu

Ayyanathan K , Lechner MS, Bell P, Maul GG, Schultz DC, Yamada Y, Tanaka K, Torigoe K, Rauscher III FJ (2003). Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation. Genes and Development: 17 : 1855-69.

Schultz DC , Ayyanathan K, Negorev D, Maul GG, Rauscher III FJ (2002). SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes and Development : 16: 919-32.

Fredericks WJ, Ayyanathan K, Rauscher III FJ (2001). Regulating the neoplastic phenotype using engineered transcriptional repressors. Cancer Letters 162 : S23-S32.

Ayyanathan K , Fredericks WJ, Berking C, Herlyn M, Balakrishnan C, Gunther E, Rauscher III FJ (2000). Hormone-dependent tumor regression in vivo by an inducible transcriptional repressor directed at the PAX3-FKHR oncogene. Cancer Research 60: 5803-14.

Fredericks WJ, Ayyanathan K, Herlyn M, Friedman JR, Rauscher III FJ (2000). An engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogene. Molecular and Cellular Biology 20: 5019-31.

Lou J, Cao W, Bernardin F, Ayyanathan K, Rauscher III FJ, Friedman AD (2000). Exogenous cdk4 overcomes reduced cdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF - a model for overcoming inhibition of proliferation by CBF oncoproteins. Oncogene 19: 2695-703.

Ryan RF*, Schultz DC *, Ayyanathan K*, Singh PB, Friedman JR, Fredericks WJ, Rauscher III FJ (1999). KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing. Molecular and Cellular Biology 19: 4366-78. (*equal contribution)