Research interests: molecular regulation of aging
Office: SC 261
Phone: (561) 799-8054
In the last two decades, the study of the molecular regulation of aging in model organisms, particularly in C. elegans, has greatly expanded our knowledge of aging. Multiple longevity pathways, such as insulin-like growth factor signaling, TOR signaling, dietary restriction, and mitochondrial activity, control aging in C. elegans and other organisms. Recent genetic studies indicate that autophagy, an evolutionary conserved lysosomal degradation pathway, interacts with various longevity signals in the regulation of C. elegans life span. My lab uses C. elegans as a model organism to investigate the molecular mechanisms by which autophagy regulates aging.
Aging is a risk factor for many human diseases including cancer and neurodegeneration. As a corollary, a wide variety of mutations that extend C. elegans life span confer resistance to tumorigenesis. Autophagy is involved in preventing aging, tumorigenesis and neurodegeneration in higher eukaryotes. Thus, a better understanding of the role of autophagy in controlling C. elegans life span may contribute to the understanding of these processes in mammals.
Shuyi Huang, Kailiang Jia, Ying Wang, Zheng Zhou and Beth Levine (2013). Autophagy genes function in apoptotic corpse clearance during C. elegans embryonic development. Autophagy. 9(2),138-49.
Kailiang Jia* and Beth Levine* (2010). Autophagy and Longevity: Lessons from C. elegans. Adv Exp Med Biol. 2010; 694: 47-60. *Corresponding authors.
Kailiang Jia, Collin Thomas, Muhammad Akbar, Qihua Sun, Beverley Adams-Huet, Christopher Gilpin and Beth Levine (2009). Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance. Proc Natl Acad Sci U S A. 2009 106 (34), 14564-14569.
Kailiang Jia and Beth Levine (2007). Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy 3 (6), 597-9.
Kailiang Jia, Anne C. Hart and Beth Levine (2007). Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans. Autophagy 3 (1), 21-25.
Kailiang Jia, Di Chen and Donald Riddle (2004). The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131, 3897-
Kailiang Jia, Patrice Albert and Donald Riddle (2002). DAF-9, a cytochrome P450 regulating C.elegans larval development and adult longevity. Development 129, 221-231.